Background
Glioblastoma is the most aggressive brain cancer in adults, with survival rates unchanged for 20 years. Standard treatment includes surgery, radiation, and chemotherapy, but the cancer often returns.
New Hope with Vitamin B3
Researchers at the University of Calgary are testing whether high doses of vitamin B3 (niacin) could improve outcomes for glioblastoma patients. The study found that niacin may help restore immune cells that tumors shut down, allowing them to attack cancer more effectively.
Clinical Trial Results
The Phase I/II trial enrolled 24 patients and showed:
- 82% of patients had no disease progression at six months
- A 28% improvement over expectations
- Results published in the Journal of Neuro-Oncology
Expert Insights
Lead researcher Dr. Gloria Roldan Urgoiti said: 'Anything that may help should be explored, but it requires strict protocols and safety monitoring.' Dr. Wee Yong added: 'Niacin treatment rejuvenates immune cells so they can attack and kill cancer cells.'
Safety Note
Researchers emphasize that high doses of vitamins, including niacin, can be toxic and must be used under medical supervision. The study continues, with final analysis expected after enrolling 48 participants by late 2026 or early 2027.