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Johns Hopkins Scientists Solve 20-Year Mystery Linking Gut Bacterium to Colon Cancer
Global Health 2026-11-01

Johns Hopkins Scientists Solve 20-Year Mystery Linking Gut Bacterium to Colon Cancer

Scientists at Johns Hopkins have solved a nearly 20-year mystery: a toxin produced by the common gut bacterium Bacteroides fragilis must first bind to a protein called claudin-4 on colon cells before it can damage the intestinal barrier, trigger inflammation and promote tumors. The team also developed a molecular decoy that successfully intercepted the toxin in mice, suggesting a new strategy for preventing associated colorectal cancer.

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