New Discovery for Metformin: After 60 Years, Diabetes Drug Revealed to Act on the Brain
A 2025 study reveals that the classic diabetes drug metformin works not only in the liver and gut but also through a specific pathway (Rap1 protein) in the brain to regulate blood sugar. This discovery explains part of its mechanism of action and opens new avenues for developing brain-targeted diabetes treatments and exploring its potential benefits like anti-aging.